ASLO ELISA (REF. 740201)

Enzyme Immunoassay for the quantitative determination of anti-streptolysin O in human serum and plasma.

Aid in the diagnosis of streptococcal group A infection, rheumatic fever and rheumatoid arthritis.

The serum titers of anti-streptolysin O (ASLO) may be of important diagnostic value in patients having a recent streptococcal group A infection, since the sequels of such infections include rheumatic fever, glomerulonephritis and erythema nodosum.

Increased titers of ASLO develop after the second week of infection and reach a peak in 4 to 6 weeks: this peak usually occurs shortly after the onset of rheumatic fever.

ASLO is present in most individuals in low titers since streptococcal infections are common. Therefore, comparison of ASLO titers at (bi-) weekly intervals yields more valuable information than a single determination.

Elevated or increasing ASLO titers are indicative of recent infection. The test is considered a valuable aid in the differential diagnosis of early rheumatic fever and rheumatoid arthritis (in which it is not elevated), when the clinical picture is not decisive.

The apDia ADM ELISA uses a highly specific monoclonal antibody – Clone 40D8, developed at the K.U. Leuven – that only detects adalimumab). Other anti-TNF drugs (for example infliximab and golimumab) do no interfere with the measurement. Biosimilars of Humira® (Amgevita®, Imraldi®) are equally well quantified in the apDia Adalimumab ELISA.

As an example of TDM, the use of adalimumab trough concentration measurements in inflammatory bowel disease patients is described.


ASLO KIT 96 TESTS, REF. 740201

The ELISA kits offered by apDia are validated on open ELISA automates such as the Dynex Instruments.



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