Elevated or increasing ASLO titers are indicative of recent infection. The test is considered a valuable aid in the differential diagnosis of early rheumatic fever and rheumatoid arthritis (in which it is not elevated), when the clinical picture is not decisive.
The apDia ADM ELISA uses a highly specific monoclonal antibody – Clone 40D8, developed at the K.U. Leuven – that only detects adalimumab). Other anti-TNF drugs (for example infliximab and golimumab) do no interfere with the measurement. Biosimilars of Humira® (Amgevita®, Imraldi®) are equally well quantified in the apDia Adalimumab ELISA.
As an example of TDM, the use of adalimumab trough concentration measurements in inflammatory bowel disease patients is described.